Characterization and Evaluation of Layered Bi₂WO₆ Nanosheets as a New Antibacterial Agent

• Main Authors: Maria Karollyna do Nascimento Silva Leandro (Author), João Victor Barbosa Moura (Author), Paulo de Tarso Cavalcante Freire (Author), Maria Leticia Vega (Author), Cleânio da Luz Lima (Author), Ángel Alberto Hidalgo (Author), Ana Carolina Justino de Araújo (Author), Priscilla Ramos Freitas (Author), Cicera Laura Roque Paulo (Author), Amanda Karine de Sousa (Author), Janaina Esmeraldo Rocha (Author), Lívia Maria Garcia Leandro (Author), Rakel Olinda Macedo da Silva (Author), Natália Cruz-Martins (Author), Henrique Douglas Melo Coutinho (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<b>Background</b>: Pathogenic microorganisms are causing increasing cases of mortality and morbidity, along with alarming rates of ineffectiveness as a result of acquired antimicrobial resistance. Bi₂WO₆ showed good potential to be used as an antibacterial substance when exposed to visible light. This study demonstrates for the first time the dimension-dependent antibacterial activity of layered Bi₂WO₆ nanosheets. <b>Materials and methods</b>: The synthesized layered Bi₂WO₆ nanosheets were prepared by the hydrothermal method and characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and Raman and Fourier transform infrared spectroscopy (FTIR). Antibacterial and antibiotic-modulation activities were performed in triplicate by the microdilution method associated with visible light irradiation (LEDs). <b>Results</b>: Bi₂WO₆ nanosheets were effective against all types of bacteria tested, with MIC values of 256 μg/mL against <i>Escherichia coli</i> standard and resistant strains, and 256 μg/mL and 32 μg/mL against <i>Staphylococcus aureus</i> standard and resistant strains, respectively. Two-dimensional (2D) Bi₂WO₆ nanosheets showed antibacterial efficiency against both strains studied without the presence of light. <b>Conclusions</b>: Layered Bi₂WO₆ nanosheets revealed dimension-dependent antibacterial activity of the Bi₂WO₆ system.

Item Description

10.3390/antibiotics10091068
2079-6382