Hepatorenal Syndrome Type 1: Current Challenges And Future Prospects

• Main Author: Facciorusso A (Author)
• Format: Book
• Published: Dove Medical Press, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Antonio Facciorusso Gastroenterology Unit, University of Foggia, Foggia, ItalyCorrespondence: Antonio FacciorussoGastroenterology Unit, Department of Medical Sciences, University of Foggia, AOU Ospedali Riuniti, Viale Pinto, 1, Foggia 71100, ItalyTel [phone]Fax [phone]Email [e-mail]: Renal dysfunction represents a dreadful complication of advanced liver cirrhosis. In addition to the traditional types of acute kidney injury (AKI) that can occur in the general population, cirrhotics might experience a different kind of renal dysfunction, called hepatorenal syndrome (HRS). The exact definition of HRS is a functional renal dysfunction caused by overactivity of the endogenous vasoactive systems (in particular intrarenal circulation) which lead to reduced renal perfusion. Type I HRS (HRS-1) is characterized by an abrupt deterioration in renal function (in less than 2 weeks), defined by a doubling of baseline sCr to >2.5 mg/dL or a 50% reduction in the initial 24 hrs creatinine clearance to   Keywords: kidney, liver cirrhosis, terlipressin, mortality

Item Description

1178-203X