Influence of Long Non-Coding RNAs on Human Oocyte Development

• Main Authors: Wang L (Author), Li B (Author), Cheng D (Author)
• Format: Book
• Published: Dove Medical Press, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Leitong Wang, Baoshan Li, Dongkai Cheng Embryo Laboratory, Jinghua Hospital of Shenyang, Shenyang, Liaoning Province, 110000, People's Republic of ChinaCorrespondence: Dongkai Cheng, Embryo Laboratory, Jinghua Hospital of Shenyang, No. 83, Zhongshan Road, Heping District, Shenyang, Liaoning Province, 110000, People's Republic of China, Tel [phone], Email [e-mail]: Recent research findings have highlighted the pivotal roles played by lncRNAs in both normal human development and disease pathogenesis. LncRNAs are expressed in oocytes and early embryos, and their expression levels change dynamically once the embryonic genome is activated during early human embryonic development. Abnormal expression of lncRNAs was found in follicular fluid, granulosa cells and oocytes of patients, and these lncRNAs were related to cell proliferation and apoptosis, nuclear maturation and follicle development. The expression levels of some lncRNAs in cumulus cells demonstrate correlations with the quality of oocytes and early embryos. This paper aims to present a comprehensive overview of the influence of LncRNAs on the developmental process of human oocytes as well as their involvement in certain infertility-related diseases.Keywords: cumulus cells, female infertility, lncRNA, oocyte

Item Description

1178-7066