Probability of Target Attainment of Tobramycin Treatment in Acute and Chronic <i>Pseudomonas aeruginosa</i> Lung Infection Based on Preclinical Population Pharmacokinetic Modeling

• Main Authors: Bruna Bernar Dias (Author), Fernando Carreño (Author), Victória Etges Helfer (Author), Priscila Martini Bernardi Garzella (Author), Daiane Maria Fonseca de Lima (Author), Fabiano Barreto (Author), Bibiana Verlindo de Araújo (Author), Teresa Dalla Costa (Author)
• Formato: Libro
• Publicado: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Biofilms and infectious process may alter free antimicrobial concentrations at the site of infection. Tobramycin (TOB), an aminoglycoside used to treat lung infections caused by <i>Pseudomonas aeruginosa</i>, binds to alginate present in biofilm extracellular matrix increasing its minimu...