The Role of Drug Transporters in the Kidney: Lessons from Tenofovir

• Main Authors: Darren Michael Moss (Author), Megan eNeary (Author), Andrew eOwen (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2014-11-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor tenofovir, shows high efficacy and relatively low toxicity in HIV patients. However, long-term kidney toxicity is now acknowledged as a modest but significant risk for tenofovir-containing regimens, and continuo...