Beyond Adherence Thresholds: A Simulation Study of the Optimal Classification of Longitudinal Adherence Trajectories From Medication Refill Histories

• Main Authors: Samuel S. Allemann (Author), Dan Dediu (Author), Alexandra Lelia Dima (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Background: The description of adherence based on medication refill histories relies on the estimation of continuous medication availability (CMA) during an observation period. Thresholds to distinguish adherence from non-adherence typically refer to an aggregated value across the entire observation...