Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic and Glycemic Outcomes Comparable to Its Subcutaneous Injection in Rats

• Main Authors: Jeferson Ziebarth (Author), Letícia Marina da Silva (Author), Ariane Krause Padilha Lorenzett (Author), Ingrid Delbone Figueiredo (Author), Paulo Fernando Carlstrom (Author), Felipe Nunes Cardoso (Author), André Luiz Ferreira de Freitas (Author), Amanda Martins Baviera (Author), Rubiana Mara Mainardes (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liraglutide (LIRA) is a glucagon-like peptide-1 (GLP-1) receptor agonist renowned for its efficacy in treating type 2 diabetes mellitus (T2DM) and is typically administered via subcutaneous injections. Oral delivery, although more desirable for being painless and potentially enhancing patient adhere...