Influence of Cytochrome P450 2C19 Genotype on Helicobacter pylori Proton Pump Inhibitor-Amoxicillin-Clarithromycin Eradication Therapy: A Meta-Analysis

• Main Authors: Yuko Morino (Author), Mitsushige Sugimoto (Author), Naoyoshi Nagata (Author), Ryota Niikiura (Author), Eri Iwata (Author), Mariko Hamada (Author), Yusuke Kawai (Author), Tatsuhiro Fujimiya (Author), Hironori Takeuchi (Author), Sakae Unezaki (Author), Takashi Kawai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Proton pump inhibitors (PPIs) are the first-line treatment for acid-related diseases. The pharmacokinetics and therapeutic efficacy of PPIs, however, are influenced by genetic factors such as variants in genes encoding drug-metabolizing enzymes (e.g., cytochrome P450 2C19 [CYP2C19]) and...