Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm

• Main Authors: Weijing Cai (Author), Ranjala Ratnayake (Author), Mengxiong Wang (Author), Qi-Yin Chen (Author), Kevin P. Raisch (Author), Long H. Dang (Author), Brian K. Law (Author), Hendrik Luesch (Author)
• Format: Book
• Published: Elsevier, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Receptor tyrosine kinases (RTKs) have become major targets for anticancer therapy. However, resistance and signaling pathway redundancy has been problematic. The marine-derived apratoxins act complementary to direct kinase inhibitors by downregulating the levels of multiple of these receptors and ad...