HIV-1 Transcription Inhibition Using Small RNA-Binding Molecules

• Main Authors: Pooja Khatkar (Author), Gifty Mensah (Author), Shangbo Ning (Author), Maria Cowen (Author), Yuriy Kim (Author), Anastasia Williams (Author), Fardokht A. Abulwerdi (Author), Yunjie Zhao (Author), Chen Zeng (Author), Stuart F. J. Le Grice (Author), Fatah Kashanchi (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The HIV-1 transactivator protein Tat interacts with the transactivation response element (TAR) at the three-nucleotide UCU bulge to facilitate the recruitment of transcription elongation factor-b (P-TEFb) and induce the transcription of the integrated proviral genome. Therefore, the Tat-TAR interact...