The Protective Effect of a Newly Developed Molecular Chaperone- Inducer Against Mouse Ischemic Acute Kidney Injury
Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on rena...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2009-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Coadministration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury. Keywords:: renal ischemia-reperfusion injury, endoplasmic reticulum (ER) stress, unfolded protein response |
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| Item Description: | 1347-8613 10.1254/jphs.08272SC |