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Molecular analysis of translocations associated with Ewing sarcoma: case report

ABSTRACT We report the case of a 25-year-old female patient having a large lesion in the right breast. The core biopsy revealed a high-grade fusocellular neoplasm. Immunostains show no evidence of a specific line of differentiation. The patient underwent radical surgery and adjuvant treatment. Due t...

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Main Authors: Leonardo R. Soares (Author), Hugo A. Bayeh (Author), Izabela Cristina Albuquerque (Author), Marise A. R. Moreira (Author), Miguel A. C. Coutinho (Author), Debora F. Rodrigues (Author), Paula O. C. Queiroz (Author), Ruffo Freitas-Junior (Author)
Format: Book
Published: Sociedade Brasileira de Patologia Clínica.
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Summary:ABSTRACT We report the case of a 25-year-old female patient having a large lesion in the right breast. The core biopsy revealed a high-grade fusocellular neoplasm. Immunostains show no evidence of a specific line of differentiation. The patient underwent radical surgery and adjuvant treatment. Due to the immunohistochemical profile and the rosette arrangement in fusocellular injury, a molecular evaluation of translocations associated to the Ewing sarcoma (ES) was made. However, translocations commonly associated with this disease [t(11;22)(q24;q12)] were not observed. The present report can contribute to the diagnostic investigation of similar cases and to the pre-test orientation of the molecular evaluation.
Item Description:1678-4774
10.5935/1676-2444.20190020

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