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Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus

The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restr...

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Main Authors: Jolanta Dorota Torzecka (Author), Joanna Narbutt (Author), Anna Sysa-jedrzejowska (Author), Maciej Borowiec (Author), Anetta Ptasinska (Author), Grzegorz Woszczek (Author), Marek L. Kowalski (Author)
Format: Book
Published: Hindawi Limited, 2003-01-01T00:00:00Z.
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Summary:The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphigus vulgaris, 15 with pemphigus foliaceus) and 87 healthy controls. The HLA-DRB1 locus was typed using the polymerase chain reaction SSO method in all the patients and 152 population controls.
Item Description:0962-9351
1466-1861
10.1080/09629350310001619735

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