The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification

• Main Authors: Jacob KIRBY (Author), Makayla STANDFEST (Author), Jessica BINKLEY (Author), Charles BARNES (Author), Evan BROWN (Author), Tyler CAIRNCROSS (Author), Alex CARTWRIGHT (Author), Danielle DADISMAN (Author), Colten MOWAT (Author), Daniel WILMOT (Author), Theodore HOUSEMAN (Author), Conner MURPHY (Author), Caleb ENGELSMAN (Author), Josh HALLER (Author), Daniel JONES (Author)
• Format: Book
• Published: University of São Paulo, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Objective For treatment of medication-related osteonecrosis of the jaw, one proposed approach is the use of a topical agent to block entry of these medications in oral soft tissues. We tested the ability of phosphonoformic acid (PFA), an inhibitor of bisphosphonate entry through certain sod...