Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue

• Main Authors: Zsófia Kohajda (Author), Noémi Tóth (Author), Jozefina Szlovák (Author), Axel Loewe (Author), Gergő Bitay (Author), Péter Gazdag (Author), János Prorok (Author), Norbert Jost (Author), Jouko Levijoki (Author), Piero Pollesello (Author), Julius Gy. Papp (Author), András Varró (Author), Norbert Nagy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and PurposeThe exact mechanism of spontaneous pacemaking is not fully understood. Recent results suggest tight cooperation between intracellular Ca2+ handling and sarcolemmal ion channels. An important player of this crosstalk is the Na+/Ca2+ exchanger (NCX), however, direct pharmacologic...