Comparative Evaluation Of Topical Preparations In Treatment of Melasma

• Main Authors: Pandhi Roma (Author), Kaur I (Author), Handa S (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2002-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0019-5154; 1998-3611
• Keywords: Dermatology; RL1-803
• Source: Indian Journal of Dermatology, Vol 47, Iss 2, Pp 76-79 (2002)

Fifty patients of melasma were randomly taken up for the study and were divided into five treatment groups of 10 patients each. Patients of these groups received clobetasol propionate 0.05% (group I), tretinoin 0.025% (group II), hydroquinone 2% (group III), bebzoyl peroxide 5% (group IV) and glycolic acid 10% (group V). Pretreatment evolution was done with MASI (melasma area severity index) scoring and photographic records. Patients were treated for 3 months and the preparations were found to be equally compatible to our patients. However, effectiveness on an average was higher for clobetasol (80%) and tretinoin (62%), though hydroquinone (48%), benzoyal peroxide (41%) and glycolic acid (30%) also showed fairly good results. Our study broadens the therapeutic spectrum of melasm by using agents with different mechanisms of action.