A Role for H₂O₂ and TRPM2 in the Induction of Cell Death: Studies in KGN Cells

• Main Authors: Carsten Theo Hack (Author), Theresa Buck (Author), Konstantin Bagnjuk (Author), Katja Eubler (Author), Lars Kunz (Author), Doris Mayr (Author), Artur Mayerhofer (Author)
• Format: Book
• Published: MDPI AG, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies showed that KGN cells, derived from a human granulosa cell tumor (GCT), express NADPH oxidase 4 (NOX4), an important source of H₂O₂. Transient receptor potential melastatin 2 (TRPM2) channel is a Ca²⁺ permeable catio...