Disruption of the NlpD lipoprotein of the plague pathogen Yersinia pestis affects iron acquisition and the activity of the twin-arginine translocation system.

• Main Authors: Avital Tidhar (Author), Yinon Levy (Author), Ayelet Zauberman (Author), Yaron Vagima (Author), David Gur (Author), Moshe Aftalion (Author), Ofir Israeli (Author), Theodor Chitlaru (Author), Naomi Ariel (Author), Yehuda Flashner (Author), Anat Zvi (Author), Emanuelle Mamroud (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously shown that the cell morphogenesis NlpD lipoprotein is essential for virulence of the plague bacteria, Yersinia pestis. To elucidate the role of NlpD in Y. pestis pathogenicity, we conducted a whole-genome comparative transcriptome analysis of the wild-type Y. pestis strain and an...