Macrophages and cancer stem cells: a malevolent alliance

Abstract Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because their pro-tumor and immunosuppressive functions are relevant for disease progression and therapeutic responses. The functional ambiguity of tumor-associated macrophages (TAMs), mostly promoting tu...

Full description

Saved in:
Bibliographic Details
Main Authors: Paola Allavena (Author), Elisabeth Digifico (Author), Cristina Belgiovine (Author)
Format: Book
Published: BMC, 2021-09-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_17a8307f1ed8457a9a7d6a8f0737bd4b
042 |a dc 
100 1 0 |a Paola Allavena  |e author 
700 1 0 |a Elisabeth Digifico  |e author 
700 1 0 |a Cristina Belgiovine  |e author 
245 0 0 |a Macrophages and cancer stem cells: a malevolent alliance 
260 |b BMC,   |c 2021-09-01T00:00:00Z. 
500 |a 10.1186/s10020-021-00383-3 
500 |a 1076-1551 
500 |a 1528-3658 
520 |a Abstract Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because their pro-tumor and immunosuppressive functions are relevant for disease progression and therapeutic responses. The functional ambiguity of tumor-associated macrophages (TAMs), mostly promoting tumor evolution, is a challenging hurdle. This is even more evident in the case of cancer stem cells (CSCs); as active participants in the specialized environment of the cancer stem cell niche, TAMs initiate a reciprocal conversation with CSCs. TAMs contribute to protect CSCs from the hostile environment (exogenous insults, toxic compounds, attacks from the immune cells), and produce several biologically active mediators that modulate crucial developmental pathways that sustain cancer cell stemness. In this review, we have focused our attention on the interaction between TAMs and CSCs; we describe how TAMs impact on CSC biology and, in turn, how CSCs exploit the tissue trophic activity of macrophages to survive and progress. Since CSCs are responsible for therapy resistance and tumor recurrence, they are important therapeutic targets. In view of the recent success in oncology obtained by stimulating the immune system, we discuss some macrophage-targeted therapeutic strategies that may also affect the CSCs and interrupt their malevolent alliance. 
546 |a EN 
690 |a Cancer stem cells 
690 |a Tumor associated macrophages 
690 |a Stemness 
690 |a GPNMB 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
690 |a Biochemistry 
690 |a QD415-436 
655 7 |a article  |2 local 
786 0 |n Molecular Medicine, Vol 27, Iss 1, Pp 1-14 (2021) 
787 0 |n https://doi.org/10.1186/s10020-021-00383-3 
787 0 |n https://doaj.org/toc/1076-1551 
787 0 |n https://doaj.org/toc/1528-3658 
856 4 1 |u https://doaj.org/article/17a8307f1ed8457a9a7d6a8f0737bd4b  |z Connect to this object online.