Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage

• Main Authors: Jianhua Zeng (Author), Hao Huang (Author), Yan Zhang (Author), Xin Lv (Author), Jiawei Cheng (Author), Si Jue Zou (Author), Yuanyuan Han (Author), Songkai Wang (Author), Li Gong (Author), Zhangzhe Peng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Renal fibrosis is a common pathological outcome of various chronic kidney diseases, and as yet, there is no specific treatment. Dapagliflozin has shown renal protection in some clinical trials as a glucose-lowering drug, but its role and mechanism on renal fibrosis remain unclear. In this study, we...