Platelet and ferritin as early predictive factors for the development of macrophage activation syndrome in children with Kawasaki disease: A retrospective case-control study

• Main Authors: Hua-yong Zhang (Author), Min Xiao (Author), Dan Zhou (Author), Fan Yan (Author), Yong Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2296-2360; 10.3389/fped.2023.1088525
• Keywords: kawasaki disease; macrophage activation syndrome; early predictive factor; children; retrospective case-control study; Pediatrics; RJ1-570
• Source: Frontiers in Pediatrics, Vol 11 (2023)

ObjectiveTo investigate the early predictive factors for Kawasaki disease complicated with macrophage activation syndrome (KD-MAS)MethodsWe performed a retrospective case-control study in children with KD from August 2017 to August 2022, involving 28 cases with KD-MAS and 112 cases not developing KD-MAS. Based on the univariate analysis, binary logistic regression was used to identify the early predictive factors for KD-MAS development, and the receiver operating characteristic curve (ROC) analysis was carried out to obtain the optimal cut-off value.ResultsTwo predictive factors were associated with the development of KD-MAS, which were PLT (OR = 1.013, 95%CI, 1.001-1.026), and serum ferritin (OR = 0.991, 95%CI, 0.982-0.999). The cut-off value of PLT was 110 × 109/L, and the cut-off value of serum ferritin was 548.4 ng/ml.ConclusionChildren with KD who had a PLT count under 110 × 109/L, and a serum ferritin level over 548.4 ng/ml are more likely to develop KD-MAS.