Preclinical Testing of Chronic ICA-1S Exposure: A Potent Protein Kinase C-ι Inhibitor as a Potential Carcinoma Therapeutic

• Main Authors: Christopher A. Apostolatos (Author), Wishrawana S. Ratnayake (Author), Sloan Breedy (Author), Jacqueline Kai Chin Chuah (Author), James Alastair Miller (Author), Daniele Zink (Author), Marie Bourgeois (Author), Mildred Acevedo-Duncan (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma cells. Previous in vitro studies have shown that 5-amino-1-((1R,2S,3R,4R)-2-3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-1H-imidazole-4-carboxamide (ICA-1S), a PKC-ι...