Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis

• Main Authors: Xue Wang (Author), Jialing Zhong (Author), Fang Chen (Author), Kang Hu (Author), Suhong Sun (Author), Yuanxiu Leng (Author), Xumei Chen (Author), Fengjiao Gan (Author), Yana Pan (Author), Qing Luo (Author)
• Format: Book
• Published: BMC, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Abstract Background We have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer. Methods An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association. Results A total of 17 case-control publications were selected. This meta-analysis showed that H19 rs217727 has a significant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive models (T vs C: OR = 1.16, 95% CI = 1.06-1.27, I 2  = 75.7; TT vs CC: OR = 1.29, 95% CI = 1.06-1.56, I 2  = 71.6; CT vs CC: OR = 1.15, 95% CI = 1.01-1.31, I 2  = 75.4; CT + TT vs CC: OR = 1.20, 95% CI = 1.05-1.36, I 2  = 76.5; TT vs CT + CC: OR = 1.22, 95% CI = 1.02-1.45, I 2  = 70.6;). In the subgroup analysis of smoking status, both smokers and nonsmokers showed an increase in cancer risk in allelic, homozygous, dominant and heterozygote models. Conclusion This meta-analysis revealed H19 rs217727 may influence cancer susceptibility.

Item Description

10.1186/s12881-019-0904-x
1471-2350