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Antinociceptive and Antipruritic Effects of HSK21542, a Peripherally-Restricted Kappa Opioid Receptor Agonist, in Animal Models of Pain and Itch

Kappa opioid receptor (KOR) agonists have been promising therapeutic candidates, owing to their potential for relieving pain and treating intractable pruritus. Although lacking morphine-like central nervous system (CNS) effects, KOR agonists do elicit sedation, dysphoria and diuresis which seriously...

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Main Authors: Xin Wang (Author), Xiaoli Gou (Author), Xiaojuan Yu (Author), Dongdong Bai (Author), Bowei Tan (Author), Pingfeng Cao (Author), Meilin Qian (Author), Xiaoxiao Zheng (Author), Hairong Wang (Author), Pingming Tang (Author), Chen Zhang (Author), Fei Ye (Author), Jia Ni (Author)
Format: Book
Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
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