Neonatal pharmacology and clinical implications

During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the progressive increase in weight and the maturation...

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Bibliographic Details
Main Authors: Antonio Ruggiero (Author), Anna Ariano (Author), Silvia Triarico (Author), Michele Antonio Capozza (Author), Pietro Ferrara (Author), Giorgio Attinà (Author)
Format: Book
Published: BioExcel Publishing Ltd, 2019-10-01T00:00:00Z.
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LEADER 00000 am a22000003u 4500
001 doaj_18a91f1a47ab4ad6bb5ae1bbb097c7cd
042 |a dc 
100 1 0 |a Antonio Ruggiero  |e author 
700 1 0 |a Anna Ariano  |e author 
700 1 0 |a Silvia Triarico   |e author 
700 1 0 |a Michele Antonio Capozza  |e author 
700 1 0 |a Pietro Ferrara  |e author 
700 1 0 |a Giorgio Attinà  |e author 
245 0 0 |a Neonatal pharmacology and clinical implications 
260 |b BioExcel Publishing Ltd,   |c 2019-10-01T00:00:00Z. 
500 |a 10.7573/dic.212608 
500 |a 1740-4398 
500 |a 1740-4398 
520 |a During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the progressive increase in weight and the maturation of the elimination pathways. In this article, we analyse the main pharmacokinetic aspects (absorption, distribution, metabolism and excretion) that exist during the neonatal period, to offer a description of the physiological background for variability in pharmacological dosing. 
546 |a EN 
690 |a infant 
690 |a newborn 
690 |a pharmacology 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Drugs in Context, Vol 8, Pp 1-9 (2019) 
787 0 |n https://www.drugsincontext.com/neonatal-pharmacology-and-clinical-implications/ 
787 0 |n https://doaj.org/toc/1740-4398 
787 0 |n https://doaj.org/toc/1740-4398 
856 4 1 |u https://doaj.org/article/18a91f1a47ab4ad6bb5ae1bbb097c7cd  |z Connect to this object online.