Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group

• Main Authors: Pasquale Linciano (Author), Luca Pinzi (Author), Silvia Belluti (Author), Ugo Chianese (Author), Rosaria Benedetti (Author), Davide Moi (Author), Lucia Altucci (Author), Silvia Franchini (Author), Carol Imbriano (Author), Claudia Sorbi (Author), Giulio Rastelli (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone deacetylase 6 (HDAC6) is an established drug target for cancer treatment. Inhibitors of HDAC6 based on a hydroxamic acid zinc binding group (ZBG) are often associated with undesirable side effects. Herein, we describe the identification of HDAC6 inhibitors based on a completely new 3-hydroxy...