A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Päätekijät: Srinivasan Chinnapaiyan (Tekijä), Maria-Jose Santiago (Tekijä), Kingshuk Panda (Tekijä), Md. Sohanur Rahman (Tekijä), Jessica Alluin (Tekijä), John Rossi (Tekijä), Hoshang J. Unwalla (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2023-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...