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L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity

Citrulline (C<sub>6</sub>H<sub>13</sub>N<sub>3</sub>O<sub>3</sub>) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a term...

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Bibliographic Details
Main Authors:	Diego Ramírez-Contreras (Author), Sergio Vázquez-Rodríguez (Author), Amalia García-García (Author), Lisset Noriega (Author), Angel Mendoza (Author), Brenda L. Sánchez-Gaytán (Author), Francisco J. Meléndez (Author), María Eugenia Castro (Author), Maura Cárdenas-García (Author), Enrique González-Vergara (Author)
Format:	Book
Published:	MDPI AG, 2024-05-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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Summary:	Citrulline (C<sub>6</sub>H<sub>13</sub>N<sub>3</sub>O<sub>3</sub>) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal ureido group on its aliphatic chain, which also appears to coordinate. Here, two new mixed complexes of citrulline were made with 1,10-phenanthroline and 2,2'-bipyridine. These compounds, once dissolved in water, gave aquo-complexes that were subject to DFT studies and in vitro toxicity studies on cancer cell lines (HeLa, MDA-MB-231, HCT 15, and MCF7) showed promising results. Docking studies with DNA were also conducted, indicating potential anticancer properties.
Item Description:	10.3390/pharmaceutics16060747 1999-4923