L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity
Citrulline (C<sub>6</sub>H<sub>13</sub>N<sub>3</sub>O<sub>3</sub>) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a term...
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2024-05-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_1938b0cc41ff493b9e940c36d4568c2c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Diego Ramírez-Contreras |e author |
| 700 | 1 | 0 | |a Sergio Vázquez-Rodríguez |e author |
| 700 | 1 | 0 | |a Amalia García-García |e author |
| 700 | 1 | 0 | |a Lisset Noriega |e author |
| 700 | 1 | 0 | |a Angel Mendoza |e author |
| 700 | 1 | 0 | |a Brenda L. Sánchez-Gaytán |e author |
| 700 | 1 | 0 | |a Francisco J. Meléndez |e author |
| 700 | 1 | 0 | |a María Eugenia Castro |e author |
| 700 | 1 | 0 | |a Maura Cárdenas-García |e author |
| 700 | 1 | 0 | |a Enrique González-Vergara |e author |
| 245 | 0 | 0 | |a L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity |
| 260 | |b MDPI AG, |c 2024-05-01T00:00:00Z. | ||
| 500 | |a 10.3390/pharmaceutics16060747 | ||
| 500 | |a 1999-4923 | ||
| 520 | |a Citrulline (C<sub>6</sub>H<sub>13</sub>N<sub>3</sub>O<sub>3</sub>) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal ureido group on its aliphatic chain, which also appears to coordinate. Here, two new mixed complexes of citrulline were made with 1,10-phenanthroline and 2,2'-bipyridine. These compounds, once dissolved in water, gave aquo-complexes that were subject to DFT studies and in vitro toxicity studies on cancer cell lines (HeLa, MDA-MB-231, HCT 15, and MCF7) showed promising results. Docking studies with DNA were also conducted, indicating potential anticancer properties. | ||
| 546 | |a EN | ||
| 690 | |a citrulline | ||
| 690 | |a anticancer | ||
| 690 | |a mixed-copper complexes | ||
| 690 | |a 1,10-phenanthroline | ||
| 690 | |a 2,2-bipyridine | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 16, Iss 6, p 747 (2024) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/16/6/747 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1938b0cc41ff493b9e940c36d4568c2c |z Connect to this object online. |