Higher doses of naloxone are needed in the synthetic opioid era

• Autori principali: Ronald B. Moss (Autore), Dennis J. Carlo (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2019-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract There has been a dramatic increase of deaths due to illicit fentanyl. We examined the pharmacology of fentanyl and reviewed data on the number of repeat doses of naloxone used to treat fentanyl overdoses. Multiple sequential doses of naloxone have been required in a certain percentage of op...