Recent Advance in Small Molecules Targeting RhlR of <i>Pseudomonas</i> <i>aeruginosa</i>

• Main Authors: Taehyeong Lim (Author), So-Young Ham (Author), SangJin Nam (Author), Myoungsun Kim (Author), Ki Yong Lee (Author), Hee-Deung Park (Author), Youngjoo Byun (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<i>Pseudomonas</i> <i>aeruginosa</i> (<i>P</i>. <i>aeruginosa</i>) is an opportunistic gram-negative pathogen that can cause various infections, particularly in patients with compromised host defenses. <i>P</i>. <i>aeruginosa</i> forms biofilms and produces virulence factors through quorum sensing (QS) network, resulting in resistance to antibiotics. RhlI/RhlR, one of key QS systems in <i>P</i>. <i>aeruginosa</i>, is considered an attractive target for inhibiting biofilm formation and attenuating virulence factors. Several recent studies examined small molecules targeting the RhlI/RhlR system and their in vitro and in vivo biological activities. In this review, RhlR-targeted modulators, including agonists and antagonists, are discussed with particular focus on structure-activity relationship studies and outlook for next-generation anti-biofilm agents.

Item Description

10.3390/antibiotics11020274
2079-6382