The impact of Lacticaseibacillus paracasei GMNL-143 toothpaste on gingivitis and oral microbiota in adults: a randomized, double-blind, crossover, placebo-controlled trial

• Main Authors: Min-Kang Lee (Author), I-Hui Chen (Author), I-Ling Hsu (Author), Wan-Hua Tsai (Author), Tzong-Yi Lee (Author), Jhih-Hua Jhong (Author), Bai-Chia Liu (Author), Tsui-Yin Huang (Author), Fang-Kuei Lin (Author), Wen-Wei Chang (Author), Ju-Hui Wu (Author)
• Format: Book
• Published: BMC, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Abstract Background This study examines the oral health benefits of heat-killed Lacticaseibacillus paracasei GMNL-143, particularly its potential in oral microbiota alterations and gingivitis improvement. Methods We assessed GMNL-143's in vitro interactions with oral pathogens and its ability to prevent pathogen adherence to gingival cells. A randomized, double-blind, crossover clinical trial was performed on gingivitis patients using GMNL-143 toothpaste or placebo for four weeks, followed by a crossover after a washout. Results GMNL-143 showed coaggregation with oral pathogens in vitro, linked to its surface layer protein. In patients, GMNL-143 toothpaste lowered the gingival index and reduced Streptococcus mutans in crevicular fluid. A positive relationship was found between Aggregatibacter actinomycetemcomitans and gingival index changes, and a negative one between Campylobacter and gingival index changes in plaque. Conclusion GMNL-143 toothpaste may shift oral bacterial composition towards a healthier state, suggesting its potential in managing mild to moderate gingivitis. Trial registration ID NCT04190485 ( https://clinicaltrials.gov/ ); 09/12/2019, retrospective registration.

Item Description

10.1186/s12903-024-04251-4
1472-6831