Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications
Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal transducer and activator of transcription 3 (STAT3...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Open Exploration Publishing Inc.,
2024-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_19a1036e9af5474ea04471f002fd127f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Taiga Maemoto |e author |
| 700 | 1 | 0 | |a Yuto Sasaki |e author |
| 700 | 1 | 0 | |a Fumiya Okuyama |e author |
| 700 | 1 | 0 | |a Yuichi Kitai |e author |
| 700 | 1 | 0 | |a Kenji Oritani |e author |
| 700 | 1 | 0 | |a Tadashi Matsuda |e author |
| 245 | 0 | 0 | |a Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications |
| 260 | |b Open Exploration Publishing Inc., |c 2024-03-01T00:00:00Z. | ||
| 500 | |a 10.37349/etat.2024.00216 | ||
| 500 | |a 2692-3114 | ||
| 520 | |a Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal transducer and activator of transcription 3 (STAT3)-binding motif in its C-terminal region. STAP-2 is also a substrate of breast tumor kinase (BRK). STAP-2/BRK expression is deregulated in breast cancers and enhances STAT3-dependent cell proliferation. In prostate cancer cells, STAP-2 interacts with and stabilizes epidermal growth factor receptor (EGFR) after stimulation, resulting in the upregulation of EGFR signaling, which contributes to cancer-cell proliferation and tumor progression. Therefore, inhibition of the interaction between STAP-2 and BRK/EGFR may be a possible therapeutic strategy for these cancers. For this purpose, peptides that interfere with STAP-2/BRK/EGFR binding may have great potential. Indeed, the identified peptide inhibitor successfully suppressed the STAP-2/EGFR protein interaction, EGFR stabilization, and cancer-cell growth. Furthermore, the peptide inhibitor suppressed tumor formation in human prostate- and lung-cancer cell lines in a murine xenograft model. This review focuses on the inhibitory peptide as a promising candidate for the treatment of prostate and lung cancers. | ||
| 546 | |a EN | ||
| 690 | |a signal-transducing adaptor protein | ||
| 690 | |a signal transduction | ||
| 690 | |a epidermal growth factor receptor | ||
| 690 | |a prostate cancer | ||
| 690 | |a lung cancer | ||
| 690 | |a peptides | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 2, Pp 251-259 (2024) | |
| 787 | 0 | |n https://www.explorationpub.com/Journals/etat/Article/1002216 | |
| 787 | 0 | |n https://doaj.org/toc/2692-3114 | |
| 856 | 4 | 1 | |u https://doaj.org/article/19a1036e9af5474ea04471f002fd127f |z Connect to this object online. |