Trophoblast-Expression of Interleukin-6 (IL-6) and Human Chorionic Gonadotropin (hCG) inWomen with Recurrent Abortion ComparedWith Normal Pregnancy
Objective: We studied the estimation of IL-6 and hCG expression in immunohistochemistry in women with unexplained Recurrent Spontaneous Abortion (RSA) and find out whether or not IL-6 regulates human Chorionic Gonadotropin release (hCG). An immunohistochemistry technique was performed to detect and...
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| Main Authors: | , , |
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| Format: | Book |
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College of Pharmacy / Mustansiriyah University,
2008-06-01T00:00:00Z.
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| Summary: | Objective: We studied the estimation of IL-6 and hCG expression in immunohistochemistry in women with unexplained Recurrent Spontaneous Abortion (RSA) and find out whether or not IL-6 regulates human Chorionic Gonadotropin release (hCG). An immunohistochemistry technique was performed to detect and determine the immunohistochemistry expression of IL-6 and hCG proteins using paraffin embedded sections of curettage samples obtained from 50 women, who were divided into three groups: 25 women with RSA, 15 women with abortion for the first time, and 10 women with induced abortion. The levels of the immunohistochemistry expression of both IL-6 and hCG were found to be highly significant increased in group 3 as compared with group 1 and group 2 (P<0.001), with a significant positive correlation between these two parameters (P<0.05) in three groups. The trophoblasts expression of IL-6 might play a role in stimulation of the expression of hCG during pregnancy. |
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| Item Description: | 10.32947/ajps.v5i1.398 1815-0993 2959-183X |