Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues
Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and car...
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| Main Authors: | , |
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| Format: | Book |
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BioExcel Publishing Ltd,
2019-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney disease (CKD), oncology, and a variety of nonmalarial infections. These clinical advancements are primarily related to pleiotropic pharmacological actions of these drugs, including immunomodulation, anti-inflammatory properties, and capabilities of inducing autophagy and apoptosis at a cellular level. Historically, many clinical benefits in nonmalarial indications were first recognized through serendipitous observations; however, with numerous ongoing systematic clinical studies, the clinical horizons of these drugs have a promising future. |
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| Item Description: | 10.7573/dic.2019-9-1 1740-4398 1740-4398 |