Ether Derivatives of Naringenin and Their Oximes as Factors Modulating Bacterial Adhesion

Because of the close connection between adhesion and many vital cellular functions, the search for new compounds modulating the adhesion of bacteria belonging to the intestinal microbiota is a great challenge and a clinical need. Based on our previous studies, we discovered that <i>O</i>...

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Main Authors: Anna Duda-Madej (Author), Joanna Kozłowska (Author), Dagmara Baczyńska (Author), Paweł Krzyżek (Author)
Format: Book
Published: MDPI AG, 2023-06-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Anna Duda-Madej  |e author 
700 1 0 |a Joanna Kozłowska  |e author 
700 1 0 |a Dagmara Baczyńska  |e author 
700 1 0 |a Paweł Krzyżek  |e author 
245 0 0 |a Ether Derivatives of Naringenin and Their Oximes as Factors Modulating Bacterial Adhesion 
260 |b MDPI AG,   |c 2023-06-01T00:00:00Z. 
500 |a 10.3390/antibiotics12061076 
500 |a 2079-6382 
520 |a Because of the close connection between adhesion and many vital cellular functions, the search for new compounds modulating the adhesion of bacteria belonging to the intestinal microbiota is a great challenge and a clinical need. Based on our previous studies, we discovered that <i>O</i>-lkyl naringenin derivatives and their oximes exhibit antimicrobial activity against antibiotic-resistant pathogens. The current study was aimed at determining the modulatory effect of these compounds on the adhesion of selected representatives of the intestinal microbiota: <i>Escherichia coli</i>, a commensal representative of the intestinal microbiota, and <i>Enterococcus faecalis</i>, a bacterium that naturally colonizes the intestines but has disease-promoting potential. To better reflect the variety of real-life scenarios, we performed these studies using two different intestinal cell lines: the physiologically functioning ("healthy") 3T3-L1 cell line and the disease-mimicking, cancerous HT-29 line. The study was performed in vitro under static and microfluidic conditions generated by the Bioflux system. We detected the modulatory effect of the tested <i>O</i>-alkyl naringenin derivatives on bacterial adhesion, which was dependent on the cell line studied and was more significant for <i>E. coli</i> than for <i>E. faecalis</i>. In addition, it was noticed that this activity was affected by the concentration of the tested compound and its structure (length of the carbon chain). In summary, <i>O</i>-alkyl naringenin derivatives and their oximes possess a promising modulatory effect on the adhesion of selected representatives of the intestinal microbiota. 
546 |a EN 
690 |a adhesion 
690 |a biofilm 
690 |a Bioflux 
690 |a microfluidic conditions 
690 |a naringenin derivatives 
690 |a intestinal microflora 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antibiotics, Vol 12, Iss 6, p 1076 (2023) 
787 0 |n https://www.mdpi.com/2079-6382/12/6/1076 
787 0 |n https://doaj.org/toc/2079-6382 
856 4 1 |u https://doaj.org/article/19d8a168c994492ba42c99b06742d96e  |z Connect to this object online.