Network Pharmacology-Guided Development of a Novel Integrative Regimen to Prevent Acute Graft-vs.-Host Disease

• Main Authors: Ming Lyu (Author), Zhengcan Zhou (Author), Xiaoming Wang (Author), Hong Lv (Author), Mei Wang (Author), Guixiang Pan (Author), Yuefei Wang (Author), Guanwei Fan (Author), Xiumei Gao (Author), Yuxin Feng (Author), Yan Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lapses in the graft-vs.-host disease (GVHD) prophylaxis and side effects of current standard care following allogeneic hematopoietic stem cell transplantation (allo-HSCT) call for novel regimens. Traditional approaches targeting T cells showed limited success in preventing acute GVHD (aGVHD). System...