Herpes simplex virus-1 triggered hemophagocytic lymphohistiocytosis in a patient with granulomatosis with polyangiitis
Hemophagocytic lymphohistiocytosis (HLH) is a rare, aggressive hyperinflammatory syndrome in which an inciting event triggers massive, uninhibited activation of T lymphocytes and macrophages. Although viral infections are the most common trigger of HLH, cases of HSV-1 induced HLH are rare in adults....
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University of São Paulo,
2022-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_1a01ca9e00d342e4b11a534b0b2ff7bc | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Vanessa A. States |e author |
| 700 | 1 | 0 | |a Meghan E. Kapp |e author |
| 245 | 0 | 0 | |a Herpes simplex virus-1 triggered hemophagocytic lymphohistiocytosis in a patient with granulomatosis with polyangiitis |
| 260 | |b University of São Paulo, |c 2022-08-01T00:00:00Z. | ||
| 500 | |a 2236-1960 | ||
| 520 | |a Hemophagocytic lymphohistiocytosis (HLH) is a rare, aggressive hyperinflammatory syndrome in which an inciting event triggers massive, uninhibited activation of T lymphocytes and macrophages. Although viral infections are the most common trigger of HLH, cases of HSV-1 induced HLH are rare in adults. We present the case and postmortem findings of a 27-year-old woman diagnosed with HLH in the setting of immunosuppression for the treatment of granulomatosis with polyangiitis (GPA). Autopsy revealed evidence of herpes simplex virus-1 (HSV-1) infection and no findings suggestive of GPA recurrence. | ||
| 546 | |a EN | ||
| 690 | |a Herpes simplex | ||
| 690 | |a Lymphocytes | ||
| 690 | |a Lymphohistiocytosis | ||
| 690 | |a Hemophagocytic | ||
| 690 | |a Macrophages | ||
| 690 | |a Vasculitis | ||
| 690 | |a Medicine | ||
| 690 | |a R | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Autopsy and Case Reports, Vol 12 (2022) | |
| 787 | 0 | |n https://www.revistas.usp.br/autopsy/article/view/201145 | |
| 787 | 0 | |n https://doaj.org/toc/2236-1960 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1a01ca9e00d342e4b11a534b0b2ff7bc |z Connect to this object online. |