HIV-1 Gag Non-Cleavage Site PI Resistance Mutations Stabilize Protease/Gag Substrate Complexes In Silico via a Substrate-Clamp

• Huvudupphovsman: Gary S. Laco (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: MDPI AG, 2021-11-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

HIV-1 protease active site inhibitors are a key part of antiretroviral therapy, though resistance can evolve rendering therapy ineffective. Protease inhibitor resistance typically starts with primary mutations around the active site, which reduces inhibitor binding, protease affinity for substrate c...