Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease-A Systematic Literature Review
Acne vulgaris is a multifactorial disease that remains under-explored; up to date it is known that the bacterium <i>Cutibacterium acnes</i> is involved in the disease occurrence, also associated with a microbial dysbiosis. Antibiotics have become a mainstay treatment generating the emerg...
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| Main Authors: | , , |
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| Format: | Book |
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MDPI AG,
2022-07-01T00:00:00Z.
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| Summary: | Acne vulgaris is a multifactorial disease that remains under-explored; up to date it is known that the bacterium <i>Cutibacterium acnes</i> is involved in the disease occurrence, also associated with a microbial dysbiosis. Antibiotics have become a mainstay treatment generating the emergence of antibiotic-resistant bacteria. In addition, there are some reported side effects of alternative treatments, which indicate the need to investigate a different therapeutic approach. Natural products continue to be an excellent option, especially those extracted from actinobacteria, which represent a prominent source of metabolites with a wide range of biological activities, particularly the marine actinobacteria, which have been less studied than their terrestrial counterparts. Therefore, this systematic review aimed to identify and evaluate the potential anti-infective activity of metabolites isolated from marine actinobacteria strains against bacteria related to the development of acne vulgaris disease. It was found that there is a variety of compounds with anti-infective activity against <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>, bacteria closely related to acne vulgaris development; nevertheless, there is no report of a compound with antibacterial activity or quorum-sensing inhibition toward <i>C. acnes</i>, which is a surprising result. Since two of the most widely used antibiotics for the treatment of acne targeting <i>C. acnes</i> were obtained from actinobacteria of the genus <i>Streptomyces</i>, this demonstrates a great opportunity to pursue further studies in this field, considering the potential of marine actinobacteria to produce new anti-infective compounds. |
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| Item Description: | 10.3390/antibiotics11070965 2079-6382 |