Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model

• Main Authors: Bachuki Shashikadze (Author), Libera Valla (Author), Salvo Danilo Lombardo (Author), Cornelia Prehn (Author), Mark Haid (Author), Fabien Riols (Author), Jan Bernd Stöckl (Author), Radwa Elkhateib (Author), Simone Renner (Author), Birgit Rathkolb (Author), Jörg Menche (Author), Martin Hrabĕ de Angelis (Author), Eckhard Wolf (Author), Elisabeth Kemter (Author), Thomas Fröhlich (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To gain mechanistic insights into adverse effects of maternal hyperglycemia on the liver of neonates, we performed a multi-omics analysis of liver tissue from piglets developed in genetically diabetic (mutant INS gene induced diabetes of youth; MIDY) or wild-type (WT) pigs. Methods: Prote...