Proteomics: a tool to develop novel diagnostic methods and unravel molecular mechanisms of pediatric diseases

Proteomics is the study of the expression of changes and post-translational modifications (PTM) of proteins along a metabolic condition either normal or pathological. In the field of health, proteomics allows obtaining valuable data for treatment, diagnosis or pathophysiological mechanisms of differ...

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Main Authors: Angélica Torres-Arroyo (Author), Arturo Ruiz-Lara (Author), Adriana Castillo-Villanueva (Author), Sara Teresa Méndez-Cruz (Author), Sara Elvia Espinosa-Padilla (Author), Francisco Javier Espinosa-Rosales (Author), Flora Zarate-Mondragón (Author), Roberto Cervantes-Bustamante (Author), Vanessa Bosch-Canto (Author), Iris Vizzuett-López (Author), Juan Carlos Ordaz-Fávila (Author), Jesús Oria-Hernández (Author), Horacio Reyes-Vivas (Author)
Format: Book
Published: Permanyer, 2017-05-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Angélica Torres-Arroyo  |e author 
700 1 0 |a Arturo Ruiz-Lara  |e author 
700 1 0 |a Adriana Castillo-Villanueva  |e author 
700 1 0 |a Sara Teresa Méndez-Cruz  |e author 
700 1 0 |a Sara Elvia Espinosa-Padilla  |e author 
700 1 0 |a Francisco Javier Espinosa-Rosales  |e author 
700 1 0 |a Flora Zarate-Mondragón  |e author 
700 1 0 |a Roberto Cervantes-Bustamante  |e author 
700 1 0 |a Vanessa Bosch-Canto  |e author 
700 1 0 |a Iris Vizzuett-López  |e author 
700 1 0 |a Juan Carlos Ordaz-Fávila  |e author 
700 1 0 |a Jesús Oria-Hernández  |e author 
700 1 0 |a Horacio Reyes-Vivas  |e author 
245 0 0 |a Proteomics: a tool to develop novel diagnostic methods and unravel molecular mechanisms of pediatric diseases 
260 |b Permanyer,   |c 2017-05-01T00:00:00Z. 
500 |a 1665-1146 
500 |a 10.1016/j.bmhimx.2017.03.009 
520 |a Proteomics is the study of the expression of changes and post-translational modifications (PTM) of proteins along a metabolic condition either normal or pathological. In the field of health, proteomics allows obtaining valuable data for treatment, diagnosis or pathophysiological mechanisms of different illnesses. To illustrate the aforementioned, we describe two projects currently being performed at the Instituto Nacional de Pediatría: The immuno-proteomic study of cow milk allergy and the Proteomic study of childhood cataract. Cow's milk proteins (CMP) are the first antigens to which infants are exposed and generate allergy in some of them. In Mexico, the incidence of CMP allergy has been estimated at 5-7%. Clinical manifestations include both gastrointestinal and extra-gastrointestinal symptoms, making its diagnosis extremely difficult. An inappropriate diagnosis affects the development and growth of children. The goals of the study are to identify the main immune-reactive CMP in Mexican pediatric population and to design more accurate diagnostic tools for this disease. Childhood cataract is a major ocular disease representing one of the main causes of blindness in infants; in developing countries, this disease promotes up to 27% of cases related to visual loss. From this group, it has been estimated that close to 60% of children do not survive beyond two years after vision lost. PTM have been pointed out as the main cause of protein precipitation at the crystalline and, consequently, clouding of this tissue. The study of childhood cataract represents an outstanding opportunity to identify the PTM associated to the cataract-genesis process. 
546 |a EN 
546 |a ES 
690 |a Spectrometry 
690 |a Proteomics 
690 |a Childhood cataract 
690 |a Milk allergy 
690 |a Pediatrics 
690 |a RJ1-570 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Boletín Médico del Hospital Infantil de México, Vol 74, Iss 3, Pp 233-240 (2017) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S1665114617300308 
787 0 |n https://doaj.org/toc/1665-1146 
856 4 1 |u https://doaj.org/article/1a45d53bc6f44dc6ba97645a460a0eb0  |z Connect to this object online.