Evaluation of Natural Extracts in Animal Models of Pain and Inflammation for a Potential Therapy of Hemorrhoidal Disease

The aim of this work was to assess the analgesic effect of three <i>Vitis vinifera</i> L. leaf extracts and the anti-inflammatory effect of three gels obtained from <i>Aesculus hippocastanum</i> L. seed extracts using animal models, as a preliminary study for the future devel...

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Main Authors: Dragos Paul Mihai (Author), Oana Cristina Seremet (Author), Georgiana Nitulescu (Author), Maria Ivopol (Author), Ani-Simona Sevastre (Author), Simona Negres (Author), Gabriel Ivopol (Author), George Mihai Nitulescu (Author), Octavian Tudorel Olaru (Author)
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Published: MDPI AG, 2019-06-01T00:00:00Z.
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001 doaj_1a4cca3ce9c341a3aae94d5b3e88e831
042 |a dc 
100 1 0 |a Dragos Paul Mihai  |e author 
700 1 0 |a Oana Cristina Seremet  |e author 
700 1 0 |a Georgiana Nitulescu  |e author 
700 1 0 |a Maria Ivopol  |e author 
700 1 0 |a Ani-Simona Sevastre  |e author 
700 1 0 |a Simona Negres  |e author 
700 1 0 |a Gabriel Ivopol  |e author 
700 1 0 |a George Mihai Nitulescu  |e author 
700 1 0 |a Octavian Tudorel Olaru  |e author 
245 0 0 |a Evaluation of Natural Extracts in Animal Models of Pain and Inflammation for a Potential Therapy of Hemorrhoidal Disease 
260 |b MDPI AG,   |c 2019-06-01T00:00:00Z. 
500 |a 2218-0532 
500 |a 10.3390/scipharm87020014 
520 |a The aim of this work was to assess the analgesic effect of three <i>Vitis vinifera</i> L. leaf extracts and the anti-inflammatory effect of three gels obtained from <i>Aesculus hippocastanum</i> L. seed extracts using animal models, as a preliminary study for the future development of topical preparations based on the combination of extracts with synergistic therapeutic effects on hemorrhoid disease. The analgesic effect was determined by means of the writhing test in mice. The anti-inflammatory effect was determined after administration of carrageenan or kaolin in the rat paw. Extraction using glycerol yielded the highest amounts of flavonoids for both <i>V. vinifera</i> leaves (37.27 &#177; 1.174 mg/L) and <i>A. hippocastanum</i> seeds (53.48 &#177; 0.212 mg/L). The highest total phenolic contents were registered for the <i>V. vinifera</i> 20% ethanolic extract (615.3 &#177; 34.44 mg/L) and for the <i>A.</i> <i>hippocastanum</i> glycerolic extract (247.8 &#177; 6.991 mg/L). The writhing test revealed that the <i>V. vinifera</i> ethanolic extract induced the most efficient analgesia (57.20%, <i>p</i> &lt; 0.01), better than that induced by the positive control. In the carrageenan inflammation model, only the gel obtained from the <i>A. hippocastanum</i> glycerolic extract significantly reduced paw edema (17.27%, <i>p</i> &lt; 0.05). An anti-inflammatory effect was also observed in the kaolin inflammation model but was not statistically significant (10.12%, <i>p</i> &gt; 0.05). Our findings indicate that <i>V. vinifera</i> and <i>A. hippocastanum</i> extracts may have potential uses for the treatment of pain and inflammation associated with hemorrhoid disease. 
546 |a EN 
690 |a hemorrhoids 
690 |a inflammation 
690 |a pain 
690 |a plant extracts 
690 |a horse chestnut 
690 |a grapevine 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Scientia Pharmaceutica, Vol 87, Iss 2, p 14 (2019) 
787 0 |n https://www.mdpi.com/2218-0532/87/2/14 
787 0 |n https://doaj.org/toc/2218-0532 
856 4 1 |u https://doaj.org/article/1a4cca3ce9c341a3aae94d5b3e88e831  |z Connect to this object online.