Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway

• Main Authors: Jianzhen Lin (Author), Ao Jiao (Author), Wu Lv (Author), Chengshuo Zhang (Author), Yue Shi (Author), Zhaoming Yang (Author), Ning Sun (Author), Xiaohang Li (Author), Jialin Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human islet amyloid polypeptide (hIAPP), the major component of islet amyloid deposition, is one of the amyloidogenic peptides and has been associated with β cell loss and dysfunction in type 2 diabetes (T2D). Autophagy plays a central role in the clearance of hIAPP aggregates, thereby diminishi...