Interaction between <i>Akkermansia muciniphila</i> and Diet Is Associated with Proinflammatory Index in School-Aged Children

• Main Authors: Juan Carlos Ayala-García (Author), Alba Mariel García-Vera (Author), Alfredo Lagunas-Martínez (Author), Yaneth Citlalli Orbe-Orihuela (Author), Ana Cristina Castañeda-Márquez (Author), Cinthya Estefhany Díaz-Benítez (Author), Víctor Hugo Bermúdez-Morales (Author), Miguel Cruz (Author), Margarita Bahena-Román (Author), Ana Isabel Burguete-García (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: Imbalance in the intestinal microbiota can lead to chronic low-grade inflammation. Diet may influence this association. In this study, we aimed to evaluate the interaction between <i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) and dietary patterns using a proinflammatory index. Methods: We conducted a cross-sectional study with school-aged children. We quantified the relative abundance (RA) of <i>A. muciniphila</i> in feces using a polymerase chain reaction. We collected dietary information through employing a food frequency questionnaire and generated dietary patterns using principal component analysis. We generated a proinflammatory index from serum levels of interleukin-6, interleukin-10, tumor necrosis factor alpha, and adiponectin validated by receptor operating characteristic curves. We evaluated the association between <i>A. muciniphila</i> and the proinflammatory index using logistic regression, including an interaction term with dietary patterns. Results: We found that children with a low RA of <i>A. muciniphila</i> and a high intake of simple carbohydrates and saturated fats had increased odds of being high on the proinflammatory index. However, when the consumption of this dietary pattern is low, children with a low RA of <i>A. muciniphila</i> had decreased odds of being high on the proinflammatory index. Conclusions: Our results suggest that the simultaneous presence of <i>A. muciniphila</i> and diet have a more significant impact on the presence of being high on the proinflammatory index compared to both factors separately.

Item Description

10.3390/children10111799
2227-9067