Seasonal Impact in the Frequency of Intrahepatic Cholestasis of Pregnancy

Objective: To evaluate the presence of any seasonal variation in the frequency of intrahepatic cholestasis of pregnancy (ICP). Study Design: A total of 126 cases with ICP were compared with a cohort of 37614 pregnant women who delivered. The diagnosis ICP was performed on the basis of severe itching...

Full description

Saved in:
Bibliographic Details
Main Authors: Cem Yaşar Sanhal (Author), Korkut Dağlar (Author), Özgür Kara (Author), Ayşe Kırbaş (Author), Dilek Uygur (Author), Aykan Yücel (Author)
Format: Book
Published: Medical Network, 2016-04-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_1a7ff1c253a943a2b6e7b11f212302d5
042 |a dc 
100 1 0 |a Cem Yaşar Sanhal  |e author 
700 1 0 |a Korkut Dağlar  |e author 
700 1 0 |a Özgür Kara  |e author 
700 1 0 |a Ayşe Kırbaş  |e author 
700 1 0 |a Dilek Uygur  |e author 
700 1 0 |a Aykan Yücel  |e author 
245 0 0 |a Seasonal Impact in the Frequency of Intrahepatic Cholestasis of Pregnancy 
260 |b Medical Network,   |c 2016-04-01T00:00:00Z. 
500 |a 1300-4751 
500 |a 10.21613/GORM.2016.87 
520 |a Objective: To evaluate the presence of any seasonal variation in the frequency of intrahepatic cholestasis of pregnancy (ICP). Study Design: A total of 126 cases with ICP were compared with a cohort of 37614 pregnant women who delivered. The diagnosis ICP was performed on the basis of severe itching and the absence of dermal rash and any other hepatic disease, with the co-existence of elevated serum aminotransferase levels and/or serum bile acid concentration. For each month and season, observed and expected ICP rates were analysed and compared by using chi-square statistics. Multivariate logistic regression was performed to investigate certain parameters on cumulative risk. Results: A significantly lower frequency of ICP in winter (6/126 (4.8%), p=0.001) and a significantly higher frequency in spring (44/126 (34.9%), p=0.034) were detected. A 2.1 and 3.8-fold higher risk were found for the nulliparity and the twin pregnancy, respectively. Logistic regression analysis confirmed the significant (10-fold) decrease in the frequency of ICP in winter. The significance of spring did not persist after the adjustment. Conclusion: Main outcome of the study points at seasonality in ICP frequency. Future studies in different populations may reveal data about factors that interact with seasonality and playing roles in ICP. 
546 |a EN 
690 |a Intrahepatic cholestasis of pregnancy, Season, Frequency, Variation 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
655 7 |a article  |2 local 
786 0 |n Gynecology Obstetrics & Reproductive Medicine, Vol 22, Iss 1 (2016) 
787 0 |n http://gorm.com.tr/index.php/GORM/article/view/87 
787 0 |n https://doaj.org/toc/1300-4751 
856 4 1 |u https://doaj.org/article/1a7ff1c253a943a2b6e7b11f212302d5  |z Connect to this object online.