COVİD-19 Akut Respiratuvar Distres Sendromu Fenotiplerinde Mekanik Ventilasyon

• Main Authors: Özgür Kömürcü (Author), Sercan Küllaç (Author), Abdurrahman Yılmaz (Author), Fatma Ülger (Author)
• Format: Book
• Published: Galenos Yayinevi, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.4274/tybd.galenos.2022.30301; 2146-6416; 2147-267X
• Keywords: covid-19; acute respiratory distress syndrome; mechanical ventilation; phenotype; Medicine; R; Internal medicine; RC31-1245; Medical emergencies. Critical care. Intensive care. First aid; RC86-88.9
• Source: Türk Yoğun Bakim Derneği Dergisi, Vol 20, Iss Suppl 1, Pp 126-134 (2022)

Objective: Coronavirus disease-2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) phenotypes in lung compliance have been described in patients with COVID- 19-related ARDS. Our study examined mechanical ventilation support and its results in patients with COVID-19-related ARDS. Materials and Methods: The retrospectively planned study was performed in patients with COVID- 19-associated ARDS who were determined to have three phenotype subgroups based on the calculated static compliance (Cstat) value [type high (H) = Cstat <40 mL/cmH2O, type light (L) = Cstat ≥50 mL/cmH2O and type intermediate (Int) =40≤ Cstat <50 mL/cm H2O]. The effects of mechanical ventilation strategy on the duration of mechanical ventilation, length of stay in the intensive care unit, and mortality in COVID-19 ARDS phenotypes were investigated. Results: It was determined that the study patients were 72.3% type H, 23.4% type L, and 4.3% type Int in terms of COVID-19 ARDS phenotype. It was observed that the mechanical ventilation strategy did not affect the duration of mechanical ventilation (p=0.357), the length of stay in the intensive care unit (p=0.127), and the mortality rate (p=0.583) in all three phenotypes. Conclusion: We believe that a phenotype-independent protective ventilation strategy defined according to compliance is appropriate in patients with COVID-19-associated ARDS.