Experiences with IL-1 blockade in systemic juvenile idiopathic arthritis - data from the German AID-registry

• Main Authors: Elke Lainka (Author), Melanie Baehr (Author), Bernadette Raszka (Author), Johannes-Peter Haas (Author), Boris Hügle (Author), Nadine Fischer (Author), Dirk Foell (Author), Claas Hinze (Author), Elisabeth Weissbarth-Riedel (Author), Tilmann Kallinich (Author), Gerd Horneff (Author), Daniel Windschall (Author), Eggert Lilienthal (Author), Tim Niehues (Author), Ulrich Neudorf (Author), Rainer Berendes (Author), Rolf-Michael Küster (Author), Prasad Thomas Oommen (Author), Christoph Rietschel (Author), Thomas Lutz (Author), Frank Weller-Heinemann (Author), Klaus Tenbrock (Author), Georg Leonhard Heubner (Author), Jens Klotsche (Author), Helmut Wittkowski (Author)
• Format: Book
• Published: BMC, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with dysregulation of the innate immune system driven by cytokines. A major role is ascribed to interleukin-1β (IL-1β), supporting the autoinflammatory character of the disease and offering an effective blocking m...