Multiwalled Carbon Nanotubes as Nanomaterial Tool in the Management of Prostate Cancer: A Possible Nanoformulation Approach

• Main Authors: Raja Murugesan (Author), Raman Sureshkumar (Author), Arun Radhakrishnan (Author), Srikanth Jupudi (Author), Manisha Chennu (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Prostate cancer (PCa) is one of the leading diseases in men all over the world caused dueto over-expression of prostate-specific membrane antigen (PSMA). Currently, the detectionand targeting of PCa is one of the major challenges in the prostate gland. Therefore, Brutontyrosine kinase inhibitor molecules like ibrutinib (Ibr) loaded with nanomaterials like multiwalledcarbon nanotubes (MWCNTs), which has good physico-chemical properties maybe the best regimen to treat PCa. In this strategy, the chemically modified MWCNTs haveexcellent 'Biosensing' properties makes it easy for detecting PCa without fluorescent agentand thus targets particular site of PCa. In the present study, Ibr/MWCNTs conjugated with T30oligonucleotide may selectively target and inhibit PSMA thereby reduce the over-expressionin PCa. Hence, the proposed formulation design can extensively reduce the dosage regimenwithout any toxic effect. Additionally, the present hypothesis also revealed the binding modeof Ibr in the catalytic pocket of PSMA by in silico method. Therefore, we presume that if thishypothesis proves correct, it becomes an additional novel tool and one of the conceivabletherapeutic options in treating PCa.

Item Description

2228-5881
2251-7308
10.34172/apb.2022.053