Larvicidal and Enzymatic Inhibition Effects of <i>Annona Muricata</i> Seed Extract and Main Constituent Annonacin against <i>Aedes Aegypti</i> and <i>Aedes Albopictus</i> (Diptera: Culicidae)

• Main Authors: Alzeir Machado Rodrigues (Author), Antonio Adailson Sousa Silva (Author), Cleonilda Claita Carneiro Pinto (Author), Dayanne Lima dos Santos (Author), José Claudio Carneiro de Freitas (Author), Victor Emanuel Pessoa Martins (Author), Selene Maia de Morais (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The mosquitoes <i>Aedes aegypti</i> and <i>Aedes albopictus</i> are vectors of arboviruses that cause dengue, zika and chikungunya. Bioactive compounds from plants are environmentally sustainable alternatives to control these vectors and thus the arboviruses transmitted by them. The present study evaluated the larvicidal activity of an acetogenin-rich fraction (ACERF) and its main constituent annonacin obtained from <i>Annona muricata</i> seeds on <i>Ae. aegypti</i> and <i>Ae. albopictus</i>. The larvicidal assays were performed using different concentrations to calculate the LC₅₀ and LC₉₀ values observed 24 h after exposure to the treatment. Annonacin was more active against <i>Ae. aegypti</i> (LC₅₀ 2.65 μg·mL⁻¹) in comparison with <i>Ae. albopictus</i> (LC₅₀ 8.34 μg·mL⁻¹). In contrast, the acetogenin-rich fraction was more active against <i>Ae. albopictus</i> (LC₅₀ 3.41 μg·mL⁻¹) than <i>Ae. aegypti</i> (LC₅₀ 12.41 μg·mL⁻¹). ACERF and annonacin treated larvae of <i>Ae. aegypti</i> and <i>Ae. albopictus</i> showed significant differences in the inhibition of their metabolic enzymes when compared to untreated larvae. The results demonstrate the relevant larvicidal action of the acetogenin-rich fraction and annonacin showing the potential to develop new products for the control of <i>Ae. aegypti</i> and <i>Ae. albopictus</i>.

Item Description

1424-8247
10.3390/ph12030112